The Engelman Lab focuses on the study design and data analysis of genetic, demographic, socioeconomic, behavioral, physiological and environmental factors of complex diseases, including biomarkers and preclinical traits related to Alzheimer’s disease. We use epidemiological, statistical, and bioinformatic approaches to analyze large-scale ‘omic data, including that from whole genome array genotyping; whole-genome sequencing; DNA methylation beadchip; and metabolomic, lipidomic, and proteomic mass spectrometry. We integrate ‘omic and questionnaire data to understand, predict, prevent, and/or treat health conditions. We are especially interested in identifying interactions with modifiable factors (e.g., social, behavioral, and environmental) to inform precision medicine and health. We study multi-ethnic populations in collaboration with the Wisconsin Registry for Alzheimer’s Prevention (WRAP), Wisconsin Alzheimer’s Disease Research Center (W-ADRC), and Survey of the Health of Wisconsin (SHOW).